| Autor: |
M Valenzano, Menada, A, Papadia, P, Lorenzi, S, Costantini, G F, Bertelli, N, Ragni |
| Rok vydání: |
2004 |
| Předmět: |
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| Zdroj: |
European journal of gynaecological oncology. 25(3) |
| ISSN: |
0392-2936 |
| Popis: |
The aim of this study was to evaluate endometrial changes after five years of tamoxifen treatment by measuring endometrial thickness with transvaginal ultrasonography.Fifty-five asymptomatic postmenopausal women who had assumed tamoxifen, 20 mg daily, for five years were controlled six months after discontinuation of the therapy. Of these 42 were followed-up at 12 months. Statistical analysis was performed using the analysis of variance for repeated measures and the Anova test; p0.05 was considered statistically significant.We found a significant reduction in endometrial thickness at six months (p = 0.0046) and at 12 months (p = 0.0003) but not between six and 12 months (p = 0.06).A statistically significant reduction in endometrial thickness after discontinuation of tamoxifen therapy was found. This can probably be attributed to the cessation of the estrogenic side-effects of tamoxifen therapy. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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