| Autor: |
M, Prados, F J, Monteseirín, M I, Carranco, R, Aragón, A, Conde, J, Conde |
| Rok vydání: |
1995 |
| Předmět: |
|
| Zdroj: |
Allergologia et immunopathologia. 23(1) |
| ISSN: |
0301-0546 |
| Popis: |
The frequency of presence of various phenotypes of alpha 1-antitrypsin was studied in 31 patients with intrinsic asthma and 11 with ASA-Triad, and compared to a group of 200 people representative of the general population. The MZ and SZ phenotype is more frequent in intrinsic asthmatics (p0.00001) and MZ in ASA-Triad (p0.0005) than in the control group. No differences were found between the intrinsic asthmatics and ASA-Triad. All the patients were divided into groups according to their clinical characteristics and an increase of the MZ phenotype was observed (p0.001) in patients with: nasal polyposis, intolerance to non-steroidal anti-inflammatories, a family history of atopy and peripheral eosinophilia (p0.01). Alpha-1-antitrypsin deficiency could be important in the pathogenesis of inflammatory processes and in the clinical manifestations characteristic of patients with intrinsic asthma and ASA-Triad. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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