| Autor: |
Jia -Lu, Zheng, Shuang-Shuang, Wang, Ke-Ping, Shen, Xiao-Wei, Huang, Miao, Li, Lei, Chen, Xiao, Peng, Hong-Mei, An, Bing, Hu |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Die Pharmazie. 75(6) |
| ISSN: |
0031-7144 |
| Popis: |
Ursolic acid (UA) is found in multiple anticancer herbs and has shown anticancer effects in colorectal cancer (CRC) cells. The present study aimed to observe the effects of a combination of UA and oxaliplatin (Oxa), a frequently used chemotherapeutic drug in CRC, on human CRC RKO cells. The results showed that UA and Oxa synergistically inhibited the proliferation of RKO cells. A combination of UA and Oxa induced apoptosis in RKO cells and increased the activities of caspase-3, caspase-8, and caspase-9. Z-VAD-FMK, a caspase inhibitor, significantly antagonized UA- and Oxa-activated caspase-3, caspase-8, and caspase-9 and induced apoptosis. In addition, UA and Oxa downregulated the expression of X-linked inhibitor of apoptosis (XIAP) and Survivin in RKO cells. These observations suggested that a combination of UA and Oxa elicited synergistically anticancer effects in RKO cells and provided new evidence for potential application of UA and Oxa for CRC treatment. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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