| Autor: |
Yuki, Hitora, Kenta, Ogura, Ahmed H H, El-Desoky, Yuji, Ise, Esther D, Angkouw, Remy E P, Mangindaan, Sachiko, Tsukamoto |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Chemicalpharmaceutical bulletin. 69(8) |
| ISSN: |
1347-5223 |
| Popis: |
A new rearranged nitrogenous bisabolone-type sesquiterpene, halichonic acid B (1), was isolated from a marine sponge Axinyssa sp. together with halichonic acid (2) and (6R,7S)-7-amino-7,8-dihydro-α-bisabolene (3). The structure of 1 was determined by extensive NMR and MS analyses, revealing an unprecedented carbon framework, and its absolute configuration was elucidated by time-dependent density-functional theory (TDDFT)-based electronic circular dichroism (ECD) spectrum calculation. We propose that 1 and 2 may be biosynthesized in the same pathway, involving the reaction between farnesyl pyrophosphate and glycine, followed by cyclization. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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