[Effect of Electroacupuncture Intervention on Gastrointestinal Motility and Expression of Insulin-like Growth Factor 1 and Its Receptor Proteins in Gastric Antrum in Diabetic Gastroparesis Rats]

Autor: Jian-Wen, Yang, Yan, Peng, Hai-Jiao, Chen, Cheng-Cheng, Zhang, Wei-Wei, Liu, Li, Liu, Mi, Liu, Ya-Ping, Lin
Rok vydání: 2017
Předmět:
Zdroj: Zhen ci yan jiu = Acupuncture research. 42(4)
ISSN: 1000-0607
Popis: To observe the effect of electroacupuncture (EA) intervention of "Zusanli"(ST 36), etc. on gastrointestinal motility and levels of insulin-like growth factor 1 (IGF-1) and IGF-1 receptor (IGF-1 R) proteins in the gastric antrum in diabetic gastroparesis (DGP) rats, so as to study its mechanism underlying improvement of DGP.Fifty SD rats, half male and half female, were randomly allocated to control, model, EA acupoint, EA non-acupoint and medication (metoclopramide) groups (After modeling, the symptom integrative score, the blood glucose, IGF-1 and IGF-1 R levels were significantly increased (EA stimulation can improve gastrointestinal motility and lower blood glucose in DGP rats, which may be closely associated with its effectiveness in reducing IGF-1 and IGF-1 R immunoactivity levels in gastric antrum.
Databáze: OpenAIRE