[Left ventricular mass, diastolic function and collagen metabolism biomarkers in essential hypertension]
| Autor: | Carlos, Macías Blanco, Daniel, Fatela-Cantillo, Luis, Jiménez-Jiménez, Raúl, López Aguilar, Rafael, Moreno-Luna, Antonio, Doblas Delgado, Pablo, Stiefel |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Immunoassay Male Heart Failure Diastolic Ventricular Remodeling Enzyme-Linked Immunosorbent Assay Blood Pressure Monitoring Ambulatory Middle Aged Collagen Type I Peptide Fragments Transforming Growth Factor beta1 Logistic Models Case-Control Studies Hypertension Humans Female Hypertrophy Left Ventricular Peptides Biomarkers Procollagen Aged |
| Zdroj: | Medicina clinica. 138(4) |
| ISSN: | 1578-8989 |
| Popis: | To evaluate the association between circulating biomarkers of collagen metabolism in serum, left ventricular mass index (LVMI) and diastolic dysfunction in patients with resistant hypertension.Fifty-two patients with resistant hypertension and 24 healthy individuals were included. The following biomarkers of collagen metabolism were analyzed by ELISA: carboxy-terminal propeptide of procollagen type I (PICP) and transforming growth factor beta1 (TGFβ1). The biomarker C-terminal telopeptide of collagen type-I (ICTP) was assayed by electrochemiluminescence immunoassay. In the patient's group a record of 24-h blood pressure monitoring was obtained and an echocardiography was performed. Left ventricular mass was measured according to the formula of Devereux and the diastolic function according to the relation of E and A waves and mitral propagation velocity.Hypertensive patients showed higher levels of PICP and lower levels of ICTP than controls: 83.7 (24.7) vs. 55.0 (8.7), P.0001; and 175.0 (136.4) vs. 323.3 (121.3), P.0001). Hypertensive patients showed a significant relationship between PICP and LVMI (r=0.631, P.0001) and between PICP and diastolic dysfunction (r=-0.519, P.0001). The groups with and without hypertrophy, and with or without diastolic dysfunction, differed in the mentioned peptides but not in BP values.Our findings suggest that the analyzed markers of synthesis and degradation of collagen may be related to myocardial hypertrophy and diastolic dysfunction independent of blood pressure values. |
| Databáze: | OpenAIRE |
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