[Role of prostaglandins and cyclic nucleotides in the mechanism of development of drug-induced thrombocytopenia]

Autor:	A I, Abesadze, L I, Atanelishvili, L I, Akhmeteli, M G, Kvernadze, M G, Mdivnishvili
Rok vydání:	1993
Předmět:	Male Cell Membrane Daunorubicin Cell Count Hematopoietic Stem Cells Second Messenger Systems Thrombocytopenia Enzyme Activation Dogs Prostaglandins Animals Female Nucleotides Cyclic Megakaryocytes Cell Division Adenylyl Cyclases
Zdroj:	Biulleten' eksperimental'noi biologii i meditsiny. 115(4)
ISSN:	0365-9615
Popis:	The experiments on dogs have shown that at the moment of maximal thrombocytopenia, induced by using of 0.7 mg/kg rubomycin intravenous daily during 5 days, there was a sharp increase in cAMP concentration, while the content of prostaglandin E group and F2 alpha in blood decreased. Concentration of cGMP began to increase by the 10th day. We can arrive at the opinion that the rubomycin acts on the receptors of hemopoietic precursor cells' membrane. This causes the activation of adenylate-cyclase, which stimulates the formation of cAMP, causing cells' proliferation depression. This mechanism may be regarded as the restoration reaction of megakaryocyte-thrombocyte system.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::de134c5bccde91c6a515d6819c1db750 https://pubmed.ncbi.nlm.nih.gov/8049388 Zobrazit plný text záznamu