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SIV-PBj14 is atypical for a lentivirus in that infection of pig-tailed macaques usually does not result in long-term progressive disease; however, this model may potentially provide valuable information about the pathogenesis of HIV and the development of AIDS. By capitalizing on some of the unique properties of the virus and the model system discussed above, new insights may be gained in: (a) understanding pathogenic mechanisms of acute lentiviral infections, (b) dissecting lentivirus-host cell interactions, (c) evaluating the role(s) of cytokines in lentivirus-induced disease, (d) rapidly assessing therapeutic and prophylactic benefits of new drugs and vaccines, and (e) identifying regions of the viral genome that influence specific biological properties. While it is unlikely, but possible, that HIV-1 variants as virulent as SIV-PBj14 will become a threat to humans, SIV-PBj14 may possess properties important to the development of lentivirus-induced disease. An understanding of all possible virus-host interactions, from the most virulent to the most benign, may be required to make a significant, positive impact on the HIV-1 pandemic. |
