| Popis: |
20 women undergoing voluntary induced abortion for the first time who were 25-35 years old and weighed 55-65 kg. received .2 mg/kg diazepam iv and 2 mg/kg ketamine iv. 5 and 10 minutes after starting of anesthesia, 10 patients received 4 mcg/kg naloxone iv for a total dose of 8 mcg/kg. The remaining 10 patients received 2 ml of physiological solution iv twice. The interval between the administration and onset of anesthesia was 78 + or - 10.3 seconds in the control group and 79.1 + or - 12.9 seconds in the treatment group. The duration of anesthesia was 7.5 + or - .8 minutes in controls and 7.4 + or - 1 minute in the naloxone-treated group. The recuperation as measured by answering simple commands was 23.8 = or - 3 minutes in controls and 24 + or - 4.2 minutes in the naloxone group. Recognition of persons was 36.5 + or - 5.3 minutes and 36 + or - 5.2 minutes, respectively; and the regaining of spacial- temporal orientation took 75 + or - 9.8 minutes and 73.8 + or - 12.2 minutes, respectively. These figures were without statistical significance. There were 13 and 14 instances of side effects in controls and the naloxone treatment group, respectively. 1 case of delirium occurred in both groups; 3 cases of diplopia in both groups; 6 and 5 instances of floating, respectively; 3 and 4 instances of vertigo, respectively; and 1 case of vomiting in the naloxone group. 1 patient in each group considered the experience unpleasant, 4 patients each were unaffected, and 1 each judged it pleasant. The score on the scale of analgesia was 2.4 + or - 1.2 in the control group and 2.3 + or - .9 in the naloxone-treated group. In conclusion, clinical doses of naloxone did not appreciably modify the action of ketamine, and clinical doses of ketamine do not interfere the opiate receptors. |
