Integrated culture platform based on a human platelet lysate supplement for the isolation and scalable manufacturing of umbilical cord matrix-derived mesenchymal stem/stromal cells

Autor: António M, de Soure, Ana, Fernandes-Platzgummer, Francisco, Moreira, Carla, Lilaia, Shi-Hwei, Liu, Chen-Peng, Ku, Yi-Feng, Huang, William, Milligan, Joaquim M S, Cabral, Cláudia L, da Silva
Rok vydání: 2015
Předmět:
Zdroj: Journal of tissue engineering and regenerative medicine. 11(5)
ISSN: 1932-7005
Popis: Umbilical cord matrix (UCM)-derived mesenchymal stem/stromal cells (MSCs) are promising therapeutic candidates for regenerative medicine settings. UCM MSCs have advantages over adult cells as these can be obtained through a non-invasive harvesting procedure and display a higher proliferative capacity. However, the high cell doses required in the clinical setting make large-scale manufacturing of UCM MSCs mandatory. A commercially available human platelet lysate-based culture supplement (UltraGRO
Databáze: OpenAIRE