| Autor: |
Irini P, Chatziralli, George, Theodossiadis, Prodromos, Dimitriadis, Michail, Charalambidis, Antonios, Agorastos, Zisis, Migkos, Nikolaos, Platogiannis, Marilita M, Moschos, Panagiotis, Theodossiadis, Petros, Keryttopoulos |
| Rok vydání: |
2016 |
| Předmět: |
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| Zdroj: |
The Open Ophthalmology Journal |
| ISSN: |
1874-3641 |
| Popis: |
Background: Several studies have focused on oxidative stress on diabetes mellitus (DM). Our purpose was to investigate the impact of oxidative stress on progression of diabetic retinopathy (DR) in insulin-dependent type 2 DM patients, measuring serum malondialdehyde (MDA), as well as to examine the effect of vitamin E on DR progression in the above-mentioned patients. Methods: Participants in the study were 282 insulin-dependent type 2 DM patients with DR. All participants underwent a thorough ophthalmological examination, so as to grade DR, along with serum MDA measurement. All participants received 300mg vitamin E daily for 3 months and were examined again. Serum MDA pre- and post-intake of Vitamin E was the main outcome. Results: Serum MDA was positively associated with DR stage, while there was a statistically significant difference pre- and post-intake of vitamin E in all DR stages. In a subgroup analysis of patients with proliferative DR, there was a significant difference at baseline between patients who have received prior laser photocoagulation and the treatment naïve patients, while after intake of vitamin E, no statistically significant difference was noticed. Conclusion: Oxidative stress has been found to play significant role in the pathogenesis and progression of DR, while vitamin E seems to reduce MDA levels and subsequent oxidative stress, suggesting that it might have protective role in DR progression. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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