| Autor: |
Breanne S, Baker, Chantelle C, Bozynski, Emily V, Leary, Richard J, Sherwood, James A, Keeney, James L, Cook, Dana L, Duren |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Obesity surgery. 31(12) |
| ISSN: |
1708-0428 |
| Popis: |
Downstream effects of bariatric weight-loss surgery have been associated with bone resorption, potentially jeopardizing total knee arthroplasty (TKA) implant fixation/ingrowth.This case-control study sought to determine if TKA patients with history of bariatric surgery exhibit altered microanatomy of subchondral bone quality in the tibial plateau compared to controls.With IRB approval, 41 bone samples were evaluated from 12 former bariatric surgery patients and 10 sex-, age-, weight-, height-, and BMI-matched controls. Patient-Reported Outcomes Measurement Information System (PROMIS) surveys were completed prior to TKA. Tibial plateau osteochondral tissues were recovered during the TKA procedure, and samples from the medial and lateral plateaus were dissected into 1 × 2 cm sections, scanned using microcomputed tomography (µCT), and plastic-embedded for histologic sectioning/staining of undecalcified bone. Paired t tests with Bonferroni correction were performed to assess group differences.Female bariatric surgery patients had reduced osteoid/total area and greater osteoclast number asymmetry than female controls (p 0.03). No differences were noted in µCT or histologic bone parameters between bariatric and control patients when the sexes were combined. Bariatric patients self-reported worse preoperative PROMIS pain interference and physical function scores than controls (p 0.04).Similarities of subchondral bone between former bariatric surgery patients and matched controls indicate OA disease progression dominates the bone landscape in both patient groups. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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