| Autor: |
Trabelsi, Imen, Mohamed Habib, Grissa, Hamdi, Boubaker, Kaouther, Beltaief, Salma, Messous, Nejia, Tounsi, Afef, Slimani, Chehaibi, Khouloud, Wahid, Bouida, Riadh, Boukef, Mohammed Naceur, Slimene, Semir, Nouira |
| Rok vydání: |
2015 |
| Předmět: |
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| Zdroj: |
International journal of clinical and experimental medicine. 8(9) |
| ISSN: |
1940-5901 |
| Popis: |
Activity of the renin-angiotensin Aldosterone system is increased in patients with heart failure (HF). The Angiotensinogen gene and specifically M235T polymorphism has been linked to susceptibility to hypertension, coronary heart disease and atrial fibrillation. Its role in heart failure is not yet sufficiently demonstrated. The aim of the present study was to assess the association between rs699 (M235T) polymorphism and heart failure in terms of diagnosis and prognosis. We included all patients over 20 years old consulting in the Emergency Department for acute dyspnea. According to the results of the B-type natriuretic peptide (BNP level), patients were divided into two groups: HF and non-HF group. DNA study was performed for all subjects and their genotypes were identified as TT, CT or CC. Mortality was followed for one year. We included 234 patients. We found the diagnosis of HF in 73 patients out of 160 (45%). Our results showed that the frequency of the T allele was higher in HF group patients than in non-HF group (69% vs. 33%, P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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