| Autor: |
E N, Parovichnikova, G A, Kliasova, V G, Isaev, A N, Sokolov, A V, Kokhno, V V, Troitskaia, E V, Mavrina, E E, Khodunova, E N, Ustinova, E O, Gribanova, S K, Kravchenko, V V, Ryzhko, T S, Kaporskaia, O Iu, Baranova, S N, Bondarenkko, A S, Nizametdinova, E V, Kondakova, T V, Ryl'tsova, A N, Alufer'eva, O S, Samoĭlova, O P, Skamorina, L V, Gavrilova, A S, Pristupa, N A, Vopilina, T S, Konstantinova, I V, Kriuchkova, L V, Anchukova, T S, Tikunova, K D, Kaplanov, V A, Lapin, V A, Tumakov, M N, Kozmina, S A, Chernysh, E I, Podol'tseva, S M, Kulikov, Iu R, Davidian, V G, Savchenko |
| Rok vydání: |
2011 |
| Předmět: |
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| Zdroj: |
Terapevticheskii arkhiv. 83(7) |
| ISSN: |
0040-3660 |
| Popis: |
To review results of 2-year experience in execution of the protocol on the treatment of adult acute Ph-negative lymphoblastic leukemia ALL-2009.Of 111 patients registered in the study from November 2008 to December 2010 the analysis covered 96 patients from 23 hematological centers in 18 towns of the RF.Treatment according to the Protocol ALL-2009 resulted in achievement of a complete remission in 91.2% patients with low early lethality of 5.5%. Postremission lethality fell to 3.7% versus previous studies (22%). Overall 2-year survival and recurrence-free survival reached 77.6 and 78.4%, respectively. Detection of any chromosomic aberrations significantly affected recurrence-free survival: 74 vs 100% in patients with normal karyotype.Protocol All-2009 demonstrates high efficacy in moderate toxicity and good reproducibility in any hematologic center. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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