Tamarin model of pneumococcal bacteremia

Autor:	D S, Chudwin, S G, Artrip, J D, Ogden, G, Schiffman
Rok vydání:	1987
Předmět:	Male Immunization Passive Opsonin Proteins Antibodies Bacterial Pneumococcal Vaccines Disease Models Animal C-Reactive Protein Streptococcus pneumoniae Immunoglobulin M Immunoglobulin G Sepsis Streptococcal Infections Bacterial Vaccines Callitrichinae Animals Female
Zdroj:	Journal of medical primatology. 16(4)
ISSN:	0047-2565
Popis:	Tamarins (Saguinus labiatus) were utilized to study host defenses against pneumococcal bacteremia. Tamarins had a poor antibody response to immunization with varying doses of pneumococcal capsular polysaccharide (PCP) vaccine (2 of 15 positive) or to infection with serotype 7F Streptococcus pneumoniae (2 of 14 positive). Tamarins were protected against challenge with a lethal dose of serotype 7F S. pneumoniae if the bacteria were preopsonized with human immune globulin intravenous or if the tamarins were injected with the immune globulin 30 min before challenge. There was minimal protection utilizing a mouse monoclonal anti-type 7F PCP antibody.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::dd6433b359c09ec1428fec41d9c1dae6 https://pubmed.ncbi.nlm.nih.gov/3114496 Zobrazit plný text záznamu