Autor: |
N S, Babayan, D V, Guryev, N Yu, Vorobyeva, B A, Grigoryan, G L, Tadevosyan, L S, Apresyan, A K, Chigasova, E I, Yashkina, S M, Rodneva, A A, Tsishnatti, Yu A, Fedotov, N K, Sarkisyan, A T, Manukyan, R M, Aroutiounian, A N, Osipov |
Rok vydání: |
2021 |
Předmět: |
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Zdroj: |
Bulletin of experimental biology and medicine. 172(1) |
ISSN: |
1573-8221 |
Popis: |
We performed a comparative study of the colony-forming ability and the number of residual foci of DNA repair proteins in cultured human lung fibroblasts (MRC-5 cell line) after exposure to subpicosecond beams of accelerated electrons with an energy of 3.6 MeV and quasi-continuous radiation (accelerated electrons with an energy of 4 MeV and X-rays). The yield of damages causing reproductive cell death after pulsed subpicosecond radiation exposure was higher by ~1.8 times than after quasi-continuous radiation exposure. The quantitative yield of residual γH2AX foci (phosphorylated H2AX histone, a protein marker of DNA double breaks) in cells irradiated with subpicosecond beams of accelerated electrons was shown to be ~2.0- 2.5-fold higher than in cells irradiated with quasi-continuous beams of accelerated electrons. |
Databáze: |
OpenAIRE |
Externí odkaz: |
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