Tolerance to ethanol intoxication after chronic ethanol: role of GluN2A and PSD-95

Autor:	Rachel A, Daut, Erica F, Busch, Jessica, Ihne, Daniel, Fisher, Masayoshi, Mishina, Seth G N, Grant, Marguerite, Camp, Andrew, Holmes
Rok vydání:	2014
Předmět:	Mice Knockout Ethanol Central Nervous System Depressants Membrane Proteins Drug Tolerance Anxiety Receptors N-Methyl-D-Aspartate Article Substance Withdrawal Syndrome Mice nervous system mental disorders Animals Alcoholic Intoxication Disks Large Homolog 4 Protein Guanylate Kinases
Zdroj:	Addiction biology. 20(2)
ISSN:	1369-1600
Popis:	The neural and genetic factors underlying chronic tolerance to alcohol are currently unclear. The GluN2A N-methyl-D-aspartate receptors (NMDAR) subunit and the NMDAR-anchoring protein PSD-95 mediate acute alcohol intoxication and represent putative mechanisms mediating tolerance. We found that chronic intermittent ethanol exposure (CIE) did not produce tolerance [loss of righting reflex (LORR)] or withdrawal-anxiety in C57BL/6J, GluN2A or PSD-95 knockout mice assayed 2-3 days later. However, significant tolerance to LORR was evident 1 day after CIE in C57BL/6J and PSD-95 knockouts, but absent in GluN2A knockouts. These data suggest a role for GluN2A in tolerance, extending evidence that human GluN2A gene variation is involved in alcohol dependence.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::dcf35944ee2a1a44c3859ece4bd4d782 https://pubmed.ncbi.nlm.nih.gov/24397780 Zobrazit plný text záznamu Plný text