| Autor: |
Eric B, Gonzales, Cathy L, Bell-Horner, Mohammed I, Dibas, Ren-Qi, Huang, Glenn H, Dillon |
| Rok vydání: |
2007 |
| Předmět: |
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| Zdroj: |
Neuroscience letters. 431(2) |
| ISSN: |
0304-3940 |
| Popis: |
The presence of phenylalanine (F) at the 6' position of transmembrane domain 2 (TM2) in the alpha4 subunit of alpha4beta2 nicotinic receptors enhances desensitization. As the GABA A receptor affords the ability to study the influence of as few as one and as many as five Fs at this position, we have used it to investigate potential subunit- and stoichiometry-dependent effects of the TM2 6'F mutation on desensitization. Whereas the presence of one F at this position decreased extent of desensitization, desensitization was increased in all configurations that included two or more Fs at the TM2 6' position; desensitization was particularly rapid with 3 or 4 F residues present. Our results demonstrate the ability of F residues at the TM2 6' position to modulate desensitization is likely conserved in the cys-loop family of ligand-gated ion channels. Moreover, our findings demonstrate both stoichiometric- and subunit-dependent effects of the ability of this mutation to regulate desensitization in GABA A receptors. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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