| Autor: |
Man, Luo, Lian-Wen, Zheng, Yu-Si, Wang, Ji-Cheng, Huang, Zhan-Qing, Yang, Zhan-Peng, Yue, Bin, Guo |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Foodfunction. 12(18) |
| ISSN: |
2042-650X |
| Popis: |
Polycystic ovarian syndrome (PCOS) is a complex endocrinopathy in women of reproductive age and the main cause of female infertility, but there is no universal drug for PCOS therapy. As a predominant dietary isoflavone present in soybeans, genistein (GEN) possesses estrogenic and antioxidative properties, but limited information is available regarding its therapeutic potential and underlying molecular mechanism in PCOS. In this study, we found that GEN might restore the estrous cycle of PCOS mice and ameliorate the elevation of circulating T, AMH and LH levels as well as LH/FSH ratios along with reduced cystic follicles, indicating the importance of GEN in PCOS therapy. Meanwhile, GEN improved the ovarian secretion function of PCOS mice and attenuated oxidative damage of the ovary through enhancing its antioxidant capability dependent on ER. Supplementation of GEN improved the defect of the ATP level and mitochondrial membrane potential, indicating the significance of GEN in preventing mitochondrial dysfunction. Further analysis demonstrated that GEN |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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