Systemic effects of collagen-impregnated aortoiliac Dacron vascular prostheses on platelet activation and fibrin formation
| Autor: | J C, De Mol Van Otterloo, J H, Van Bockel, E D, Ponfoort, E, Briet, E J, Brommer, J, Hermans, M R, Daha |
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| Rok vydání: | 1991 |
| Předmět: |
Adult
Aged 80 and over Male Fibrin Polyethylene Terephthalates Graft Occlusion Vascular Arterial Occlusive Diseases Middle Aged Platelet Activation beta-Thromboglobulin Iliac Artery Aortic Aneurysm Blood Vessel Prosthesis Femoral Artery Fibrin Fibrinogen Degradation Products Humans Female Collagen Aorta Aged Fibrinopeptide A |
| Zdroj: | Journal of vascular surgery. 14(1) |
| ISSN: | 0741-5214 |
| Popis: | To minimize intraoperative blood loss a watertight knitted Dacron aortoiliac prosthesis has been developed by impregnation with bovine collagen. A potential disadvantage is that collagen may be associated with an increase in thrombus formation. We conducted a prospective randomized trial to study the systemic effects of collagen-impregnated prostheses and of aortoiliac operation as such on the coagulation mechanism during the first 10 days after operation. Forty-one patients randomly received either a collagen-impregnated (n = 20) or a nonimpregnated prosthesis (n = 21). Twelve patients who underwent cholecystectomies served as controls. Three markers of the coagulation mechanism were monitored: beta-thromboglobulin, fibrinopeptide A, and fibrin/fibrinogen degradation products. We found no significant differences in median beta-thromboglobulin, fibrinopeptide A, and fibrin/fibrinogen degradation product levels between patients in the collagen-impregnated prosthesis group and patients in the nonimpregnated prosthesis group. This indicates that collagen does not stimulate the coagulation cascade any more than conventional Dacron protheses do. In a comparison of patients who underwent aortoiliac reconstruction and patients who underwent cholecystectomies, the results indicated a significant increased platelet activation and fibrin metabolism in aortoiliac reconstruction group compared with the control group. Finally, we observed a significantly higher preoperative fibrin metabolism in patients with vascular disease than in control subjects. This difference is attributable to the high preoperative fibrin/fibrinogen degradation product values in patients with aortic aneurysms. |
| Databáze: | OpenAIRE |
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