| Autor: |
Yapin, Wang, Stephen, Costin, Jian-Feng, Zhang, Sumei, Liao, Zezhang T, Wen, Thomas, Lallier, Qingzhao, Yu, Xiaoming, Xu |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
American journal of dentistry. 31 |
| ISSN: |
0894-8275 |
| Popis: |
To synthesize a small library of antibacterial dental monomers based on quaternary ammonium salts and to test their antibacterial activity against cariogenic bacteria.Five new antibacterial monomers were synthesized and characterized by NMR, IR and HRMS.Cytotoxicity assays using human gingival fibroblast cells showed that these new antibacterial monomers were biocompatible at concentrations of 10⁻⁵ M and displayed less cytotoxicity than BisGMA, a common dental monomer. When analyzed in vitro, all new monomers demonstrated strong inhibitory activity against biofilm formation by cariogenic Streptococcus mutans and Lactobacillus casei. Results indicated that antibacterial monomers containing a long alkyl (i.e. hexadecyl) chain are superior to their shorter-chain counterparts. The cross-linking monomers based on glycerol dimethacrylate also consistently outperformed their monomethacrylate analogs. Finally, the ammonium salts containing the dimethylbenzyl moiety were superior to the similar structures containing 1,4-diazabicyclo[2.2.2]octane (DABCO) in some cases.All five new monomers were deemed biocompatible at concentrations of 10⁻⁵ M or less, and most had better biocompatibility than BisGMA. Dimethacrylate monomers 5 and 6 generally demonstrated high antibacterial activities, with the highest activity shown for the most lipophilic monomer 6, and these new antibacterial monomers have potential future application in dental composites and bonding agents. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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