| Autor: |
I, Caubarrère, G, Bonan, A, Venet, J, Chebat, D, Uzzan, J, Gilbert, H, Beaufils |
| Jazyk: |
francouzština |
| Rok vydání: |
1985 |
| Předmět: |
|
| Zdroj: |
Annales de medecine interne. 136(4) |
| ISSN: |
0003-410X |
| Popis: |
Four cases of amiodarone-induced restrictive, hypoxaemic lung disease are described. The cumulative dosages of amiodarone were relatively low (30 to 100 g). Alveolar lavage studies showed a lymphocytosis and study of the lymphocytic sub-populations showed an increase in the OKT8 group, and an inversion of the OKT4/OKT8 ratio. The outcome was favourable on withdrawal of amiodarone and steroid therapy. The immunological origin of this form of lung disease was confirmed. Two patients had renal failure; in the first case, hypercalcaemia, hyperphosphoremia and renal calcification were observed. The second patient had endo- and extracapillary glomerulonephritis with C3 deposits and circulating immune complexes. Renal failure regressed in both cases on withdrawal of amiodarone and with steroid therapy. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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