| Autor: |
Shahab, Ilka, Afshin, Heshmati, Seyed Alireza, Mirabdollahi, Abdollah, Jafarzadeh, Farnaz, Sedghy, Fatemeh, Bagheri, Omid, Azari, Mohammad Ali, Mohammadi, Fatemeh, Jafari Dareh Dar, Moein, Arabnadvi |
| Rok vydání: |
2021 |
| Zdroj: |
Avicenna journal of phytomedicine. 12(3) |
| ISSN: |
2228-7930 |
| Popis: |
Following bone trauma, several factors participate in making a balance between the activity of osteoblasts and osteoclasts. The receptor activator of nuclear factor kappa B ligand (RANKL), receptor activator of nuclear factor kappa B (RANK), and osteoprotegerin (OPG) molecules play critical roles in the healing process via regulation of osteoclasts function. Turmeric is suggested to have an anti-osteogenic potential; however, its effect on accelerating bone healing has not been adequately studied. Here, we used a rat model of femur fracture to explore the effect of treatment with turmeric extract on the bone repair and the expression ofEight rats were subjected to surgery, randomly divided into two groups, and treated orally with turmeric (200 mg/kg), or olive oil. Four oil-treated rats without bone fracture were used as control group. After six weeks of treatment, the femurs of animals were examined for radiological, histological, and gene expression analysis.X-ray radiography showed thicker callus and a more obscure fracture line in the turmeric group. Furthermore, higher osteoblast percentages but no osteoclasts were observed in turmeric-treated animals, representing better repair of bone in the fracture site. Also, real-time analyses showed that treatment with turmeric reducedOur findings indicated the turmeric ability to facilitate bone hemostasis and optimize the expression of key markers involved in the bone metabolism. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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