Follicular Lymphoma Presenting With Monoclonal IgM And MYD88 Mutation: A Case Report And Review Of The Literature

Autor:	Xu, Linglong, Ding, Xiaoxiao, Ying, Limei, Zhang, Xiaochang, Lu, Nina
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	immunochemotherapy follicular lymphoma immune system diseases hemic and lymphatic diseases monoclonal gammopathy Case Report MYD88 mutation
Zdroj:	OncoTargets and therapy
ISSN:	1178-6930
Popis:	MYD88 mutation has been reported in various lymphomas, specifically in lymphoplasmacytic lymphoma. Yet, the mutation has not been reported in primary follicular lymphoma. Here, we present a 62-year-old male with follicular lymphoma who had an MYD88 L265P somatic mutation and monoclonal IgM gammopathy. He received four cycles of R-CHOP immunochemotherapy. Interim PET/CT evaluation indicated a state of stable disease (SD). Neither did serum IgM remarkably drop. He was then given a bortezomib-contained regimen which significantly reduced the level of serum IgM. To the best of our knowledge, this is the first report of follicular lymphoma with monoclonal IgM and MYD88 L265P mutation. The present case indicated bortezomib may benefit these patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::dc47da37fc680850043db8f9acd4a7a3 http://europepmc.org/articles/PMC6767481 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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