Efficacy of a live oral cholera vaccine in human volunteers

Autor: W E, Woodward, R H, Gilman, R B, Hornick, J P, Libonati, R A, Cash
Rok vydání: 1976
Předmět:
Zdroj: Developments in biological standardization. 33
ISSN: 0301-5149
Popis: A live attenuated oral cholera vaccine has been given to volunteers with complete safety. The vaccine strain appeared to multiply significantly in intestinal contents and to result in appreciable vibriocidal antibody response. Subsequent challenge with virulent Inaba vibrios demonstrated substantial protection from clinical illness and from vibrio shedding. The possibility of reversion to toxin production is discussed.
Databáze: OpenAIRE