Molybdenum sulfide–reduced graphene oxide p–n heterojunction nanosheets with anchored oxygen generating manganese dioxide nanoparticles for enhanced photodynamic therapy† †Electronic supplementary information (ESI) available: Experimental section; FESEM, AFM and TEM images; N2 sorption isotherms; Mott–Schottky plots; FTIR spectra; zeta potential; fluorescence spectra; cell viabilities; photothermal heating curves; comparison of fluorescence intensities; and live–dead cell assay. See DOI: 10.1039/c8sc02508h

Autor: Kapri, Sutanu, Bhattacharyya, Sayan
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Chemical Science
ISSN: 2041-6539
2041-6520
Popis: In an unprecedented approach, p–n heterojunction nanosheets comprising ∼5 nm thick p-type MoS2 nanoplates integrated onto n-type nitrogen doped reduced graphene oxide have been employed for photodynamic therapy.
In an unprecedented approach, p–n heterojunction nanosheets comprising ∼5 nm thick p-type MoS2 nanoplates integrated onto n-type nitrogen doped reduced graphene oxide (n-rGO) have been employed for photodynamic therapy (PDT). When near infrared (NIR) light with 980 nm wavelength was irradiated on this nanocomposite, effective electron–hole separation was obtained across the heterojunction. The nanosheets were modified with lipoic acid functionalized poly(ethylene glycol) to provide better biocompatibility and colloidal stability in physiological solution. The surface decorated 3–5 nm MnO2 nanoparticles (NPs) triggered the disproportionation of intracellular H2O2 which improved generation of reactive oxygen species (ROS) for enhanced PDT cancer therapy, studied in vitro. The role of N-doping in rGO and the effect of immobilization of MnO2 NPs were systematically investigated by control experiments. Our smartly designed p-MoS2/n-rGO–MnO2–PEG nanosheets outperform conventional PDT agents by overcoming limitations such as low absorption band, unfavourable bioavailability and limitations in tissue oxygenation.
Databáze: OpenAIRE
Externí odkaz: