| Autor: |
Naruhiko, Mizuta, Koichi, Sakaguchi, Mitsuhiko, Mizuta, Miho, Ichida, Mahiro, Ohashi, Yoshimi, Umeda, Asako, Nishiyama, Midori, Matsumoto, Ikuya, Fujiwara |
| Rok vydání: |
2010 |
| Předmět: |
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| Zdroj: |
Gan to kagaku ryoho. Cancerchemotherapy. 37(7) |
| ISSN: |
0385-0684 |
| Popis: |
We report a long-term complete response (CR) in a patient with postoperative recurrent breast cancer and bone and pleura metastases after treatment with a combination of S-1 and zoledronic acid. We administered 4 courses of tri-weekly CE (epirubicin 75 mg/m2, cyclophosphamide 600 mg/m2) and 12 courses of weekly paclitaxel (80 mg/m2) as adjuvant chemotherapy. However, combination therapy with S-1 and zoledronic acid was started because of the development of bone and pleura metastases. S-1 was administered orally at 100 mg/day everyday for 2 weeks, followed by a 1-week rest interval as 1 course; 4 mg of zoledronic acid was injected every 4 weeks. After 3 cycles of treatment, the patient's tumor marker levels had decreased to normal values, and both the bone and pleura metastases had disappeared. A long-term complete response was obtained as a result of this combination therapy. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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