| Autor: |
Y, Zhao, A A, Gopalai, A, Ahmad-Annuar, E W L, Teng, K M, Prakash, L C S, Tan, W-L, Au, H-H, Li, S-Y, Lim, S K, Lim, Y B, Chong, L P, Tan, N M, Ibrahim, E-K, Tan |
| Rok vydání: |
2012 |
| Předmět: |
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| Zdroj: |
Clinical genetics. 84(5) |
| ISSN: |
1399-0004 |
| Popis: |
A variant (rs3129882) in the genome-wide association study (GWAS)-linked variant [in the human leukocyte antigen (HLA) gene region] has been reported to associate with an increased risk of Parkinson's disease (PD) in Caucasian population. Studies among Chinese are limited. To address this, we analysed rs3129882 in a total of 1312 subjects of Chinese ethnicity from independent Asian centers comprising of 675 controls and 637 PD cases. The rs3129882 variant was associated with a decreased risk in our ethnic Chinese PD patients. Logistic regression analysis taking into consideration variables of age, gender and race showed that allele A reduced the risk of PD via a dominant model [odds ratio (OR) = 0.77, 95% confidence interval (CI) = 0.62, 0.96, p = 0.018]. As HLA is a highly polymorphic region, it is possible that ethnic-specific effect or environmental agents may modulate the effect of this GWAS-linked locus in influencing the risk of PD. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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