| Autor: |
Iu V, Lakeev, V A, Kosykh, E I, Kosenkov, V L, Novikov, A V, Lebedev, V S, Repin |
| Rok vydání: |
1992 |
| Předmět: |
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| Zdroj: |
Biulleten' eksperimental'noi biologii i meditsiny. 114(11) |
| ISSN: |
0365-9615 |
| Popis: |
Primary cultures of rabbit hepatocytes were used to examine the effect of natural and synthetic antioxidants--polyhydroxynaphthoquinones (PHNQ) and alpha-tocopherol on cholesterol and bile acid synthesis. Histochrome, one of the PHNQ, slightly decreased cholesterol synthesis at concentrations 10-100 microM, whereas alpha-tocopherol stimulated cholesterol synthesis. After administration of histochrome or alpha-tocopherol into culture medium a significant stimulation of bile acid synthesis in dose-dependent manner was observed. The increase of bile acid secretion by histochrome in the presence of physiological concentration of HDL2 was found as well. Since histochrome in contrast to alpha-tocopherol enhanced accumulation of [14C] cholesterol of HDL2 in the hepatocytes, it was concluded that histochrome stimulated bile acid synthesis as a result of increased input of HDL2 cholesterol into hepatocytes. These data suggest that histochrome may exhibit a hypocholesterolemic effect by stimulation of bile acid synthesis and inhibition of cholesterol synthesis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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