| Autor: |
M H, Doğan, B, Karadag, T, Ozyigit, S, Kayaoglu, A O, Ozturk, Y, Altuntas |
| Rok vydání: |
2012 |
| Předmět: |
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| Zdroj: |
Acta clinica Belgica. 67(5) |
| ISSN: |
1784-3286 |
| Popis: |
To investigate a possible correlation between skeletal muscle mass and hypertensive target organ damage.A total of 365 hypertensive patients aged18 years were included (221 females; 144 males). Exclusion criteria were: diabetes; hypo- or hyperthyroidism; immobilisation; leg amputation; dehydration; cancer diagnosis; renal insufficiency with GFR of60 ml/ dk/1.73 m2; and hormone replacement therapy. All patients who participated in the study were examined for the presence of hypertensive retinopathy and nephropathy and divided into four groups according to age and sex (group 1 = females aged60 years; group 2 = females aged60 years; group 3 = males aged60 years; and group 4 = males aged60 years). The diagnosis of hypertensive nephropathy and retinopathy was based on spot urine microalbuminuria/creatinine ratio and opthalmoscopy, examination respectively. Body composition was evaluated using bioimpedance analysis (BIA). Fullbody skeletal muscle mass (SMM) and SMM index (SMMI) were used as indicators of skeletal muscle mass.As expected, female and elderly subjects showed a decreased skeletal muscle mass and increased fat mass compared to males and younger subjects. In the overall cohort, a negative correlation was found between skeletal muscle mass and both hypertensive retinopathy and nephropathy. Subgroup analysis revealed a linear correlation between increased SMM and a decreased risk of hypertensive retinopathy. Patients with a spot urine microalbuminura/creatinine ratio ofor = 30 had a lower SMM and a lower SMMI than patients with a ratio of30.In the present cohort, sarcopenia mainly due to aging was associated with an increased rate of hypertensive target organ damage in the form of hypertensive retinopathy and nephropathy |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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