| Autor: |
Sven, Erickson, Sampsa, Matikainen, Lena, Thyrell, Olle, Sangfelt, Ilkka, Julkunen, Stefan, Einhorn, Dan, Grandér |
| Rok vydání: |
2002 |
| Předmět: |
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| Zdroj: |
European journal of biochemistry. 269(1) |
| ISSN: |
0014-2956 |
| Popis: |
It has previously been shown that IFN-alpha is a potent inhibitor of IL-2 induced proliferation in primary T-lymphocytes, by selectively abrogating the downstream effects of IL-2 on the core cell cycle machinery regulating the G1/S transition. Theoretically this could be mediated through cross-talk between the signalling cascades activated by these cytokines, as several signalling components are known to be shared. IL-2 activates multiple signalling pathways that are important for T-cell proliferation and differentiation. In the present study, the effects of IFN-alpha on IL-2 signal transduction was investigated. The IFN-alpha induced inhibition of IL-2 induced proliferation in activated T-lymphocytes, was associated with a suppressed Jak3 protein expression as well as an inhibited prolonged Stat5 DNA binding, and a partially reduced expression of the Stat5 inducible gene IL-2R alpha. Our results provide a possible molecular link between the prominent antiproliferative effects of IFN-alpha on IL-2 induced T-cell proliferation and the signal transduction pathways emerging from the IL-2 receptor. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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