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| Autor: | Hai-Jun, Tang, Yu-Feng, Zhang, Yi-Wen, Jiang, Chao, Feng |
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| Rok vydání: | 2018 |
| Zdroj: | Organic letters. 20(17) |
| ISSN: | 1523-7052 |
| Popis: | An efficient [3 + 2] annulation of (2,2-difluorovinyl)-2-iodoarenes and internal alkynes was developed for the synthesis of 1-(trifluoromethyl)-1 H-indenes. The success of this strategy hinges upon a well-balanced process for the generation of two transient reactive species, specifically trifluoroethylsilver and alkenylpalladium intermediates, in the same molecule, as well as a smooth transmetalation step, which delicately joins together these two different metallic intermediates. |
| Databáze: | OpenAIRE |
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