| Autor: |
W, Szmuness, R H, Purcell, J L, Dienstag, C E, Stevens |
| Rok vydání: |
1977 |
| Předmět: |
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| Zdroj: |
JAMA. 237(16) |
| ISSN: |
0098-7484 |
| Popis: |
Institutionalized patients with Down syndrome and matched controls with other causes of mental retardation were tested by immune adherence hemagglutination for the presence of antibody to hepatitis A antigen (anti-HA). Altogether 75.1% (175 of 233) exhibited presence of anti-HA, with no differences by sex or age. Patients reactive for hepatitis B surface antigen (HBsAg) or its antibody (anti-HBs) were reactive for anti-HA significantly more frequently than those with a negative reaction for these markers. In contrast to serologic markers of hepatitis type B, prevalence of anti-HA does not depend on the cause of mental retardation or on the age at primary infection. The rate of anti-HA positivity was found to be closely correlated with duration of institutionalization. The study confirmed that many closed institutions for the mentally retarded are hyperendemic for hepatitis type A and that formation of anti-HA is not greatly affected by either immune deficiency or immune immaturity. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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