| Autor: |
Sahnila, Enam, Dai-Di, Gan, Martyn K, White, Luis, Del Valle, Kamel, Khalili |
| Rok vydání: |
2006 |
| Předmět: |
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| Zdroj: |
Anticancer research. 26(2A) |
| ISSN: |
0250-7005 |
| Popis: |
Recently, the genome of the human polyomavirus, JC (JCV), and expression of its early and late regulatory proteins (T-antigen and agnoprotein) have been demonstrated in neoplastic cells of colonic cancer cases.Regulation of JCV was investigated in a human colon cancer cell line (SW480) and compared to a human glioblastoma cell line (U87-MG) that is permissive for JCV replication.SW480 cells supported basal transcription of both early and late JCV promoters. The expression of TCF-4, a component of Wnt signaling, modulated JCV transcription in a cell type-specific manner. Both TCF-4 and T-antigen bound to the JCV promoter region and bound to each other. In addition, the expression of TCF-4 caused a decrease in the ability of the T-antigen to stimulate viral DNA replication in U87-MG cells.Wnt pathway signaling proteins and T-antigen interact to regulate JCV in colonic epithelial cells. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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