Clozapine for refractory schizophrenia: the Illinois experience
| Autor: | R W, Buckman, R D, Malan |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Male Cost-Benefit Analysis Health Care Costs Middle Aged Drug Administration Schedule Drug Costs Hospitalization Treatment Outcome Clinical Protocols Schizophrenia Brief Psychiatric Rating Scale Humans Female Illinois Clozapine Algorithms Antipsychotic Agents Information Systems Retrospective Studies |
| Zdroj: | The Journal of clinical psychiatry. 60 |
| ISSN: | 0160-6689 |
| Popis: | Based upon the Illinois Department of Mental Health and Developmental Disabilities' computerized clinical information system, with its integration of client-specific clinical data, a 5-year retrospective study was designed to determine the clinical effectiveness and economic impact of the use of clozapine for treatment-resistant schizophrenia. The study sample consisted of 518 hospitalized, treatment-resistant patients. At the end of 5 years, 78% were well maintained on clozapine. Two hundred forty-three patients had been discharged to the community, and 62 had been transferred for treatment of medical or surgical problems. Clozapine treatment was discontinued in 115 patients (22%). The drug was well tolerated, with a very low incidence of agranulocytosis. Cost savings resulting from the discharge of the 243 clozapine-treated patients amounts to approximately $20 million per year. A disease management algorithm has been developed allowing physicians to begin clozapine treatment for patients not successfully treated with 2 prior antipsychotic agents. Adherence to this protocol throughout the state's mental health system would result in even greater savings. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|