TCTP from
| Autor: | Marianna, Boia-Ferreira, Kamila G, Moreno, Alana B C, Basílio, Lucas P, da Silva, Larissa, Vuitika, Bruna, Soley, Ana Carolina M, Wille, Lucélia, Donatti, Katia C, Barbaro, Olga M, Chaim, Luiza Helena, Gremski, Silvio S, Veiga, Andrea, Senff-Ribeiro |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Spider Venoms
venom Promethazine Skin Diseases TCTP Article Mice Piperidines Cromolyn Sodium Biomarkers Tumor Hypersensitivity Tumor Cells Cultured Animals Mast Cells toxin Inflammation Dose-Response Relationship Drug Phosphoric Diester Hydrolases Tumor Protein Translationally-Controlled 1 brown spider Rats Injections Intravenous HRF Rabbits Cimetidine Loxosceles Injections Intraperitoneal |
| Zdroj: | Cells |
| ISSN: | 2073-4409 |
| Popis: | LiTCTP is a toxin from the Translationally Controlled Tumor Protein (TCTP) family identified in Loxosceles brown spider venoms. These proteins are known as histamine-releasing factors (HRF). TCTPs participate in allergic and anaphylactic reactions, which suggest their potential role as therapeutic targets. The histaminergic effect of TCTP is related to its pro-inflammatory functions. An initial characterization of LiTCTP in animal models showed that this toxin can increase the microvascular permeability of skin vessels and induce paw edema in a dose-dependent manner. We evaluated the role of LiTCTP in vitro and in vivo in the inflammatory and allergic aspects that undergo the biological responses observed in Loxoscelism, the clinical condition after an accident with Loxosceles spiders. Our results showed LiTCTP recombinant toxin (LiRecTCTP) as an essential synergistic factor for the dermonecrotic toxin actions (LiRecDT1, known as the main toxin in the pathophysiology of Loxoscelism), revealing its contribution to the exacerbated inflammatory response clinically observed in envenomated patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|