Stage of differentiation, proliferative index of tumor cells and cytotoxic activity of peripheral blood lymphocytes in colorectal cancer patients

Autor:	Tatyana D, Paholyuk, Lubov M, Zacharzeva, Konstantin V, Koshel, Gennadiy P, Oliynichenko, Ninel M, Berezhnaya
Rok vydání:	2004
Předmět:	Male Cell Differentiation Adenocarcinoma Middle Aged Prognosis Killer Cells Natural Ki-67 Antigen Chemotherapy Adjuvant Lymphatic Metastasis Tumor Cells Cultured Humans Female Lymph Nodes Colorectal Neoplasms Cell Division Neoplasm Staging T-Lymphocytes Cytotoxic
Zdroj:	Experimental oncology. 26(2)
ISSN:	1812-9269
Popis:	To evaluate prognostic value of activity of cytotoxic lymphocytes of peripheral blood (CTL) of patients with colorectal cancer (CRC).2-year survival of 30 patients with colorectal cancer stage II (T2-3N0-1M0G1-3) was investigated in relation with clinical data, cytotoxic activity of peripheral blood lymphocytes (by MTT-test) and immunohistochemical peculiarities of tumor cells using anti-Ki-67-MABs.It was revealed that some factors had prognostic significance, namely regional lymph nodes involvement (r = -0.69), proliferative activity of tumor cells (Ki-67-positivity) (r = -0.67), restoration of CTL function after operation (r = 0.46), adjuvant chemotherapy (r = 0.41) and differentiation stage of tumor (r = 0.40). Negative correlation between CTL activity before operation and tumor proliferative activity also exists (r = -0.35).the data point to the involvement of natural killer cells in the control of tumor growth.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::d9fd052f2980583ca08a08c3c29f68b0 https://pubmed.ncbi.nlm.nih.gov/15273670 Zobrazit plný text záznamu