Therapeutic Antibody Against Phosphorylcholine Preserves Coronary Function and Attenuates Vascular
| Autor: | Mia, Ståhle, Johanna M U, Silvola, Sanna, Hellberg, Margreet, de Vries, Paul H A, Quax, Jeffrey, Kroon, Petteri, Rinne, Alwin, de Jong, Heidi, Liljenbäck, Nina, Savisto, Anna, Wickman, Erik S G, Stroes, Seppo, Ylä-Herttuala, Pekka, Saukko, Tommy, Abrahamsson, Knut, Pettersson, Juhani, Knuuti, Anne, Roivainen, Antti, Saraste |
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| Rok vydání: | 2019 |
| Předmět: |
18F-FDG
18F-fluorodeoxyglucose phosphorylcholine NO nitric oxide coronary flow reserve CFR coronary flow reserve ApoB apolipoprotein-B PC phosphorylcholine PC-mAb human PC antibody OxLDL oxidized low-density lipoprotein cholesterol HAEC human aortic endothelial cell Lp(a) lipoprotein(a) Ig immunoglobulin ICAM intracellular adhesion molecule IL interleukin PRECLINICAL RESEARCH inflammation OxPLs oxidized phospholipids LDLR low-density lipoprotein receptor 18F-fluorodeoxyglucose positron emission tomography atherosclerosis ANOVA analysis of variance VCAM vascular cell adhesion molecule |
| Zdroj: | JACC: Basic to Translational Science |
| ISSN: | 2452-302X |
| Popis: | Visual Abstract Highlights • Phosphorylcholine is a pro-inflammatory epitope in atherogenic oxidized phospholipids. • This study investigated effects of a novel monoclonal IgG1 antibody against PC on vascular function and atherosclerotic inflammation. • Treatment with phosphorylcholine antibody preserved coronary flow reserve and decreased uptake of 18F-FDG in atherosclerotic lesions in hypercholesterolemic mice. • Noninvasive imaging techniques represent translational tools to assess the efficacy of phosphorylcholine-targeted therapy on coronary artery function and atherosclerosis. Summary This study showed that treatment with a therapeutic monoclonal immunoglobulin-G1 antibody against phosphorylcholine on oxidized phospholipids preserves coronary flow reserve and attenuates atherosclerotic inflammation as determined by the uptake of 18F-fluorodeoxyglucose in atherosclerotic mice. The noninvasive imaging techniques represent translational tools to assess the efficacy of phosphorylcholine-targeted therapy on coronary artery function and atherosclerosis in clinical studies. |
| Databáze: | OpenAIRE |
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