Cisplatinum and interstitial laser therapy for advanced head and neck cancer: a preclinical study

Autor:	M B, Paiva, R E, Saxton, Q M, VanderWerf, T, Bell, A A, Eshraghi, I P, Graeber, J, Feyh, D J, Castro
Rok vydání:	1997
Předmět:	Male Mice Inbred BALB C Brachytherapy Mice Nude Antineoplastic Agents Injections Intralesional Middle Aged Combined Modality Therapy Mice Head and Neck Neoplasms Carcinoma Squamous Cell Animals Humans Laser Therapy Cisplatin Neoplasm Transplantation
Zdroj:	Lasers in surgery and medicine. 21(5)
ISSN:	0196-8092
Popis:	Direct intratumor injection of cisplatinum (CDDP) and laser therapy were tested for improved treatment of squamous cell carcinoma (SCCA).Human SCCA tumors were grown as s.c. transplants in nude mice and injected with CDDP (0.4-1.2 mg/gm) in water or in collagen-based gel carrier with epinephrine (epi-gel), followed by interstitial laser therapy (ILT) via 0.6 mm fiberoptics (532 nm/300 J).Tumors injected with CDDP epi-gel exhibited a partial response with 2-4-fold tumor growth delay, compared to aqueous drug or untreated SCCA transplants during 10-week follow-up. Combined drug and laser therapy significantly decreased tumor volume with recurrence in only 25% (2/8) of animals tested, compared to 66% tumor regrowth (10/15) after ILT alone.These initial results suggest laser chemotherapy may become an effective treatment for advanced head and neck cancer.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::d9f1e17da88d9589772d3f3092bfa53f https://pubmed.ncbi.nlm.nih.gov/9365952 Zobrazit plný text záznamu Plný text