| Autor: |
Yu D, Ivanov, K A, Malsagova, T O, Pleshakova, I D, Shumov, A L, Kaysheva, V P, Popov, O V, Naumova, B I, Fomin, D A, Nasimov, A V, Latyshev, A L, Aseev, V Yu, Tatur, N D, Ivanova, G M, Konovalova, A I, Archakov |
| Rok vydání: |
2017 |
| Předmět: |
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| Zdroj: |
Patologicheskaia fiziologiia i eksperimental'naia terapiia. 60(1) |
| ISSN: |
0031-2991 |
| Popis: |
A method for detection of cancer-associated protein D-NFATc1 in serum using nanowire (NW) biosensor based on field-effect nanotransistor is developed. Field-effect nanotransistor was fabricated on the basis of «silicon-on-insulator» structures. For the biospecific detection of target protein, the NW surface was modified with aptamers against the target protein. Using the 3 um-NW enabled to obtain stable source-drain characteristics and to register D-NFATc1 in serum at concentration of 2.5 x 1014 M in the mode of drain-source current vs. gate voltage characteristics measurements. Data collection in the mode of drain-source current vs. gate voltage characteristics measurements was carried out with the use of high-speed data collection system running TURBO NBS software. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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