| Autor: |
Chih-Yen, Wang, Yun-Ti, Hsieh, Kuan-Min, Fang, Chung-Shi, Yang, Shun-Fen, Tzeng |
| Rok vydání: |
2016 |
| Předmět: |
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| Zdroj: |
Journal of neuroscience research. 94(12) |
| ISSN: |
1097-4547 |
| Popis: |
CD200, a type I transmembrane glycoprotein, can interact with its receptor CD200R, which plays an inhibitory role in the activation of microglia-the resident macrophages of the central nervous system. In this study, the rat C6 glioma cell line (C6-1) that was previously characterized with high in vivo tumorigenicity was found to generate CD200 mRNA abundantly. However, CD200 expression was barely detected in another C6 glioma cell clone (C6-2) that was previously found to display low tumorigenic behavior. The results from CD200 immunohistochemistry on human glioma tissue array also showed that tumor cells in Grade I-II astrocytoma expressed a lower level of CD200 immunoreactivity than those detected in Grade III-IV glioblastoma multiforme. C6-1 transfectants with stable downregulation of CD200 gene expression using lentivirus knockdown approach were generated (C6-KD). Microglia and iNOS |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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