| Autor: |
R A, Mangiafico, L S, Malatino, M, Santonocito, R S, Spada, G, Polizzi, B, Stancanelli, C, Leonardi, G, Tamburino |
| Rok vydání: |
1993 |
| Předmět: |
|
| Zdroj: |
International angiology : a journal of the International Union of Angiology. 12(1) |
| ISSN: |
0392-9590 |
| Popis: |
To investigate the effects of postural changes and upright exercise on atrial natriuretic peptide release and renin-angiotensin-aldosterone system behavior in patients with venous valvular insufficiency, plasma ANP, plasma renin activity and aldosterone were measured in 11 patients with venous disease and in 11 age-matched controls. In patients with large varicose veins and venous valvular dysfunction, standing was associated with a greater fall in circulating ANP levels (p0.05) and upright exercise was accompanied by a smaller rise in ANP concentrations (p0.05) as compared with controls. A significant (p0.001) inverse relationship was found between the number of venous segments with reflux and both upright and exercise plasma ANP concentrations (r = -0.91; r = -0.84, respectively). In the two groups the response of the renin-angiotensin-aldosterone system to upright position and physical stress was similar. These results suggest that a decreased atrial stretch, due to a reduced venous return, could account for the blunted ANP response to erect posture and exercise in patients with venous valvular incompetency. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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