5-Iododeoxyuridine as well as 5-bromodeoxyuridine induce the formation of specific dicentric chromosomes in cells with micronuclei

Autor: V I, Stobetskiĭ, Iu Kh, Khapchaev, L L, Mironova
Rok vydání: 1987
Předmět:
Zdroj: Biulleten' eksperimental'noi biologii i meditsiny. 104(7)
ISSN: 0365-9615
Popis: 5-iododeoxyuridine used instead of 5-bromodeoxyuridine for the induction of delayed disruption of telomeric links between chromosomes in polykaryocytes consisting of micronuclei was studied. It has been shown that treatment with 5-iododeoxyuridine (20 micrograms/ml) and colcemide (0.1 microgram/ml) for 42 hours induced the dicentric formation. Dicentrics were tested in 27% of all metaphases. This index was lower in comparison with 5-bromodeoxyuridine used for the same purpose.
Databáze: OpenAIRE