Gut-homing Δ42PD1

Autor: Allen Ka Loon, Cheung, Hau-Yee, Kwok, Yiru, Huang, Min, Chen, Yufei, Mo, Xilin, Wu, Ka-Shing, Lam, Hoi-Kuan, Kong, Terrence Chi Kong, Lau, Jingying, Zhou, Jingjing, Li, Lin, Cheng, Boon, Kiat Lee, Qiaoli, Peng, Xiaofan, Lu, Minghui, An, Hui, Wang, Hong, Shang, Boping, Zhou, Hao, Wu, Aimin, Xu, Kwok-Yung, Yuen, Zhiwei, Chen
Rok vydání: 2016
Předmět:
Zdroj: Nature microbiology. 2(10)
ISSN: 2058-5276
Popis: The innate immune cells underlying mucosal inflammatory responses and damage during acute HIV-1 infection remain incompletely understood. Here, we report a Vδ2 subset of gut-homing γδ T cells with significantly upregulated Δ42PD1 (a PD1 isoform) in acute (~20%) HIV-1 patients compared to chronic HIV-1 patients (~11%) and healthy controls (~2%). The frequency of Δ42PD1
Databáze: OpenAIRE