| Autor: |
Arthur J, Van De Vyver, Tina, Weinzierl, Miro J, Eigenmann, Nicolas, Frances, Sylvia, Herter, Regula B, Buser, Jitka, Somandin, Sarah, Diggelmann, Florian, Limani, Thorsten, Lehr, Marina, Bacac, Antje-Christine, Walz |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Molecular cancer therapeutics. 20(2) |
| ISSN: |
1538-8514 |
| Popis: |
Targeted T-cell redirection is a promising field in cancer immunotherapy. T-cell bispecific antibodies (TCB) are novel antibody constructs capable of binding simultaneously to T cells and tumor cells, allowing cross-linking and the formation of immunologic synapses. This in turn results in T-cell activation, expansion, and tumor killing. TCB activity depends on system-related properties such as tumor target antigen expression as well as antibody properties such as binding affinities to target and T cells. Here, we developed a systems model integrating |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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