Chemoradiotherapy as initial management in patients with squamous cell carcinoma of the head and neck
| Autor: | D J, Adelstein, V M, Sharan, A S, Earle, A C, Shah, C, Vlastou, C D, Haria, S G, Carter, C, Damm, J D, Hines |
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| Rok vydání: | 1986 |
| Předmět: |
Adult
Male Mucous Membrane Vomiting Radiotherapy Dosage Middle Aged Combined Modality Therapy Hematologic Diseases Actuarial Analysis Head and Neck Neoplasms Antineoplastic Combined Chemotherapy Protocols Carcinoma Squamous Cell Humans Female Kidney Diseases Fluorouracil Cisplatin Aged Neoplasm Staging |
| Zdroj: | Cancer treatment reports. 70(6) |
| ISSN: | 0361-5960 |
| Popis: | Thirty-nine previously untreated or minimally treated patients with squamous cell carcinoma of the head and neck were entered onto a chemoradiotherapy protocol employing multiple courses of simultaneous radiation therapy, cisplatin, and a 4-day 5-FU infusion. Thirty-eight patients were evaluable for response and toxicity. Twenty-three patients underwent surgical resection midway through this therapy and 11 (48%) were pathologically free of disease. Thirty-five of the 38 patients (92%) were ultimately rendered disease-free by this combined modality protocol. Thirty-one patients remain disease-free, with a projected 2-year disease-free survival of 74%. Although the treatment-associated mucositis and myelo-suppression were significant, this chemoradiotherapeutic approach is promising and merits further study. |
| Databáze: | OpenAIRE |
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