| Autor: |
A I, Tukhvatulin, D Y, Logunov, I I, Gitlin, M M, Shmarov, P V, Kudan, Capital A Cyrillic А, Adzhieva, A F, Moroz, N N, Kostyukova, L G, Burdelya, B S, Naroditsky, A L, Gintsburg, A V, Gudkov |
| Rok vydání: |
2012 |
| Předmět: |
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| Zdroj: |
Acta Naturae |
| ISSN: |
2075-8251 |
| Popis: |
Pattern-recognition receptors (PRR) play a crucial role in the induction of the defense reactions of the immune system against pathogenic bacterial and viral infections. The activation of PRR by specific, highly conserved pathogen-associated molecular patterns (PAMPs) induces numerous immune reactions related both to innate and adaptive immunity. In addition to the well-studied Toll-like receptors, pathogens can be recognized by the receptors belonging to the other PRR families; including NOD-like receptors (NLR). Stimulation of members of NOD-like receptors (NOD1, 2) and Toll-like receptors results in the activation of the transcriptional factor NF-kB regulating gene expression in numerous molecules implicated in the development of proinflammatory reactions. As opposed to Toll-like receptors, the NF-kB-activating ability of NLRs has not been fully studied. In this work, we examine the ability of one member of the NLR family – NOD1 – to activate the main proinflammatory transcriptional factor NF-kB. We also compare the NF-kB-activating ability of NOD1 ligands of a different structure with TLR4,5 ligandsin vitroandin vivo. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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