[A case of neurotoxicity reduced with pregabalin in R-CHOP chemotherapy for diffuse large B-cell lymphoma]
| Autor: | Toshihisa, Nakashima, Takayoshi, Kiba, Yoshikazu, Ogawa, Akiko, Kimura, Miki, Kido, Yoshiko, Okikawa, Takuo, Ito, Akihisa, Saito, Atsuko, Hosokawa, Hiromi, Shintani, Yuko, Okada, Takako, Taniguchi, Kiyomi, Taniyama, Kazuhiro, Kozawa, Hiromasa, Niimi |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Pregabalin Peripheral Nervous System Diseases Middle Aged Kidney Antibodies Monoclonal Murine-Derived Doxorubicin Vincristine Antineoplastic Combined Chemotherapy Protocols Humans Prednisone Lymphoma Large B-Cell Diffuse Rituximab Tomography X-Ray Computed Cyclophosphamide gamma-Aminobutyric Acid Neoplasm Staging |
| Zdroj: | Gan to kagaku ryoho. Cancerchemotherapy. 39(5) |
| ISSN: | 0385-0684 |
| Popis: | When performing R-CHOP(rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone)for diffuse large B-cell lymphoma(DLBCL), neurotoxicity of vincristine(VCR)is the serious dose-limiting factor.Pregabalin is one of the first-line treatments for painful diabetic peripheral neuropathy in many countries, and we have administered it to relieve the neurotoxicity associated with adverse effects of VCR in a DLBCL patient treated with the R-CHOP regimen.A 49-year-old man with kidney DLBCL had surgery performed.Afterward, the R-CHOP regimen was introduced.In order to relieve the neurotoxicity of VCR, pregabalin was used from day 8 in the second course.The severity of sensory neurotoxicity after the administration of pregabalin was improved from CTCAE(v4.0)grade 3 to grade 1.Therefore, there is a possibility that VCR-induced neurotoxicity is relieved by pregabalin.Further trials are needed to confirm the value of pregabalin. |
| Databáze: | OpenAIRE |
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