Large-cell anaplastic non-Hodgkin's lymphoma originating in donor cells after allogenic bone marrow transplantation

Autor:	H C, Schouten, A H, Hopman, A M, Haesevoets, J W, Arends
Rok vydání:	1995
Předmět:	Herpesvirus 4 Human Tumor Virus Infections Humans Lymphoma Large-Cell Anaplastic Transplantation Homologous Female Neoplasms Second Primary Herpesviridae Infections Middle Aged Precursor Cell Lymphoblastic Leukemia-Lymphoma In Situ Hybridization Fluorescence Bone Marrow Transplantation
Zdroj:	British journal of haematology. 91(1)
ISSN:	0007-1048
Popis:	Second neoplasms after allogenic bone marrow transplantation (BMT) occur in donor cells; however, host origin generally cannot be excluded. Using fluorescence in situ hybridization (FISH) the origin of the malignant population can be proven indisputably. In a female patient with CD30+ large-cell anaplastic non-Hodgkin's lymphoma (LCAL) after BMT with an HLA-identical brother donor, FISH using anti-CD30 immunocytochemistry in combination with anti-Y- and anti-EBV RNA probes was applied. In pathological lymph nodes the majority of cells were of donor type (Y). CD30-positive cells were Y-positive; these cells were also EBV-positive. Using FISH and immunocytochemistry we have demonstrated convincingly that this, possibly EBV-induced, LCAC originated in donor cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::d908ea8fba460e178ecc9341dbb8b4de https://pubmed.ncbi.nlm.nih.gov/7577625 Zobrazit plný text záznamu Plný text