Liver involvement during influenza infection: perspective on the 2009 influenza pandemic
| Autor: | Neven, Papic, Ana, Pangercic, Martina, Vargovic, Bruno, Barsic, Adriana, Vince, Ilija, Kuzman |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Adolescent Croatia systemic inflammatory response liver Young Adult Influenza A Virus H1N1 Subtype Short Article Influenza Human Humans Aspartate Aminotransferases Child Pandemics Retrospective Studies L-Lactate Dehydrogenase hypoxia Liver Diseases H1N1 virus diseases Alanine Transaminase Short Articles gamma-Glutamyltransferase Middle Aged Part 2 (E‐only) C-Reactive Protein Alanine aminotransferase Female influenza |
| Zdroj: | Influenza and Other Respiratory Viruses |
| ISSN: | 1750-2659 |
| Popis: | Please cite this paper as: Papic et al. (2011) Liver involvement during influenza infection: perspective on the 2009 influenza pandemic. Influenza and Other Respiratory Viruses 6(3), e2–e5. Elevation of liver transaminase levels is a frequent observation during systemic infections. The aim of our study was to investigate liver damage during pandemic 2009 influenza A/H1N1 infection in comparison with seasonal influenza. Serum levels of aspartate aminotransferase, alanine aminotransferase, and gamma‐glutamyl transpeptidase (GGT) were significantly higher in patients with pandemic influenza compared to seasonal influenza, which was strongly correlated with hypoxia. Moreover, a positive correlation between C‐reactive protein and serum GGT, alkaline phosphatase, and lactate dehydrogenase was noticed. Our findings support the hypothesis that the pandemic 2009 influenza A/H1N1 is an illness with a significant immune response to infection leading to hepatocellular injury. |
| Databáze: | OpenAIRE |
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